Ampicillin sodium plus Salbactam
Generic name
Ampicillin sodium plus Salbactam
Trade name
UNASYN®
Classification
ANTI-INFECTIVE ANTIBACTERIAL AMINOPENICILLIN
Indication
Susceptible infections due to beta-lactamase producing organisms such as H. influenzae, E. coli, Klebsiella, Acinetobacter, Enterobacter, S aureus, Bacteroides species (anaerobes)
Dosage form
Ampicillin 1 G Plus Sulbactam 500 mg/vial
Dose
Susceptible infections: 1.5-3 g (1-2 g ampicillin and 0.5-1 g sulbactam) IV/IM every 6 hr
Maximum 4 g sulbactam/day
Dose adjustment
renal impairment:
CrCl 15-29 mL/min, extend interval to every 12 hr;
CrCl 5-14 mL/min, extend interval to every 24 hr
Administration
IV: Bolus or Intermittent infusion, IM
Intravenous Concentration
IV dilute with NS only 1.5 gram in 50 ml or 3 g in 100 ml
Intravenous Rate
Intermittent Infusion: ให้ยาอย่างน้อย 10 to 30 นาที
Storage
เก็บอุณหภูมิต่ำกว่า 25 C, ป้องกันแสง
Reconstitution
Reconstitution with SWFI 10 ml per 1.5 G vial
IM : Use WFI or Lidocaine 0.5 % w/v 3.2 ml per 1.5 gram
Stability
stable 4 hr (2-8 ° C) and 1 hr (25 ° C)
Compatible fluid
NS only
Incompatible fluid
AMINO ACID SOLUTIONS; SODIUM BICARBONATE
Incompatible drug
adrenaline, amikacin, aztreonam, cefepime, chlorpromazine, ciprofloxacin, dopamine, ergometrine, erythromycin, fluconazole, gentamicin, hydralazine, hydrocortisone, lignocaine, lincomycin, metoclopramide, ondansetron, prochlorperazine, tetracycline, thiopentone, verapamil
Adverse effect
ท้องเสีย ผื่น ปวดบริเวณที่ฉีด
Precaution
Contraindication
Information
