Amikacin
Generic name
Amikacin
Trade name
Amikin®
Classification
Antibacterial, Aminoglycoside
Indication
Sensitive bacterial infections including gram-positive and gram-negative organisms.
Dosage form
500 mg/ 2 ml/ vial
Dose
Adult :
5 to 7.5 mg/kg/dose every 8 to 12 hours.
Range: 15 to 25 mg/kg/24 h in divided doses.
Maximum 1.5 grams daily.
Administration
Intermittent infusion, IM
Intravenous Concentration
Intermittent Infusion: Dilute the required dose in 100 to 200 ml Not to exceed 5 mg per ml
Intravenous Rate
Intermittent Infusion: Infuse over 30 to 60 minutes.
Storage
เก็บอุณหภูมิต่ำกว่า 25 C, ป้องกันแสง
Reconstitution
Not required.
Stability
Discard any unused solution.
Compatible fluid
NSS, D5W
Incompatible fluid
Incompatible drug
amphotericin, ampicillin, benzylpenicillin, cefazolin, cloxacillin, heparin, phenytoin, vitamin B group with ascorbic acid
Adverse effect
Nephrotoxicity, ototoxicity, vestibular toxicity, hypomagnesaemia, hypocalcaemia, hypokalaemia, neuromuscular paralysis, anaphylaxis, elevated liver enzymes, anaemia, visual disturbances
Precaution
Check for hypersensitivity to amikacin or aminoglycoside before administration. Consider dosage modification in renal failure and monitor serum levels. Use caution with the concurrent use of neuromuscular blocking agents and other ototoxic or nephrotoxic drugs. Use with caution in pregnancy, myasthenia gravis and pre-existing cochlear or vestibular impairment.
Contraindication
