Aminophylline
Generic name
Theophylline ethylenediamine
Trade name
Classification
BRONCHODILATOR THEOPHYLLINE DERIVATIVE
Indication
Bronchodilator, pulmonary vasodilator, cardiac stimulant, coronary vasodilator, cerebral stimulant.
Dosage form
250mg in 10mL, ampoule
Dose
Adult : Loading dose: 6 mg/kg. Maintenance : 0.1 to 1 mg/kg/hour.
Administration
IV: Bolus, Intermittent infusion or Continuous infusion
Intravenous Concentration
Bolus: Undiluted. Not for routine administration
Intermittent Infusion: 500 mg in 100 mL. (5 mg per mL)
Continuous Infusion: 500 mg in 250 mL. (2 mg per mL)
Intravenous Rate
Bolus: Slow injection. Not to exceed 25 mg per minute.
Intermittent Infusion: Infuse over 20 to 30 minutes
Continuous Infusion: 0.05 to 0.5 mL/kg/hour (0.1 to 1 mg/kg/hour).
Storage
เก็บอุณหภูมิต่ำกว่า 25 C, ป้องกันแสง
Reconstitution
Not required.
Stability
Discard any unused solution.
Compatible fluid
NSS, D5W, Ringer’S
Incompatible fluid
Incompatible drug
adrenaline, amiodarone, ascorbic acid, atracurium, benzylpenicillin, bleomycin, cefepime, cefotaxime, ceftriaxone, chlorpromazine, ciprofloxacin, clindamycin, codeine, dobutamine, doxorubicin, erythromycin, hydralazine, insulin, isoprenaline, methadone, methylprednisolone, morphine, noradrenaline, ondansetron, pentazocine, pethidine, phenytoin, procaine, prochlorperazine, promazine, promethazine, sulphadiazine, tetracycline, vitamin B group with ascorbic acid
Adverse effect
Irritability, diarrhoea, restlessness, tachycardia, life-threatening cardiac dysrhythmias, convulsions, hypotension, syncope, cardiac arrest
Precaution
Check for hypersensitivity to aminophylline (theophylline) before administration. Consider dosage modification in patients with cardiac failure, hepatic dysfunction and in asphyxiated or premature
Contraindication
