Cloxacillin sodium
Generic name
Cloxacillin sodium
Trade name
Classification
ANTI-INFECTIVE ANTIBACTERIAL PENICILLIN
Indication
Sensitive bacterial infections including staphylococci and other gram-positive coccal infections.
Dosage form
500 mg, 1 gram powder/vial
Dose
Adult: 500 mg to 2 grams every 6 hours.
Cellulitis,pneumonia: mild to moderate infection: 1 gram IV q 6 hours; severe infection: 2 grams IV q 6 h
Endocarditis,meningitis,osteomyelitis: 2 grams IV q 4 hours
Child: 40 kg and over: as for ‘Adult’.
Less than 40 kg: 25 to 50 mg/kg/day in divided doses every 6 hours.
Dose adjustment
Administration
IV: Bolus, Intermittent infusion, continous infusion, IM
Intravenous Concentration
Bolus: 1 gram per 10 mL
Intermittent Infusion: 1 to 2 grams in 100 to 250 mL
Continuous Infusion: 1 to 2 grams in 500 mL Recommended concentration 2 mg per ml
Intravenous Rate
Bolus: Inject slowly over 5 minutes.
Intermittent Infusion: Administer over at least 60 minutes.
Continuous Infusion: Infuse over 6 to 12 hours.
Storage
Store below 25 ° C. ป้องกันแสง
Reconstitution
WFI 10 mL per gram.
Stability
Stable for 72 hours at 5 ° C and 24 hours at 25° C.
Compatible fluid
NS; D5W
Incompatible fluid
Incompatible drug
amikacin, ciprofloxacin, colistin, gentamicin, lincomycin, netilmicin, tobramycin
Adverse effect
Precaution
Contraindication
Information
